SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease

Authors

Mridula Bhalla, Jinhyeong Joo, Daeun Kim, Jeong Im Shin, Yongmin Mason Park, Yeon Ha Ju, Uiyeol Park, Seonguk Yoo, Seung Jae Hyeon, Hyunbeom Lee, Junghee Lee, Hoon Ryu, C Justin Lee

Topic

Neuroscience

Extract

"Images at 510 nm wavelength were taken after excitation by 340 nm and 380 nm light using pE-340fura (CoolLED) to record calcium transients within the cells. The two resulting images were used for ratio calculations in Axon Imaging Workbench (version 11.3, Axon Instruments)."

Product Type

pE-340^fura

Journal

Molecular Degeneration

Year of Publication

2025

Read the full research paper here

Custom Microscopy Illumination

Need something a little different?

For manufacturers who wish to gain a competitive advantage through bright, stable and controllable illumination, CoolLED’s world-renowned LED technology is available in customised configurations.

Streamlined development using proven off-the-shelf technology
Professional support
Market-leading warranty
‘Try before you buy’ option
Trusted experts in LED illumination technology since 2006

LEARN MORE

Sustainability

Did you know that LED illumination systems help laboratories reduce their carbon footprint, protecting laboratory staff along the way?

Toxic mercury-based microscope illuminators are bad news for the environment, draw a lot of power and have a short lifetime.

LED illumination systems are cleaner, have a long lifetime and use less power. Our pE-300 Series is also ACT label certified and is a natural choice for labs who want to play their part in helping the environment.