Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer’s disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance

Authors

Giulia Dematteis, Chunmei Gong, Justyna Malecka, Elisa Tonelli, Armando Genazzani, Laura Tapella, Anna Maria Eleuteri, Dmitry Lim, Laura Bonfili

Topic

Cell Biology

Extract

"After that, cells were fixed in 4% paraformaldehyde, mounted on microscopy slides and analysed using a Leica DMi8 epifluorescent microscope equipped with CoolLED pE4000 light source, HC PL FLUOTAR (340) 40x/1.30 OIL objective, and Hamamatsu Flash 4.0 V3 camera."

Product Type

pE-4000

Journal

Alzheimer's Research & Therapy

Year of Publication

2025

Read the full research paper here

Custom Microscopy Illumination

Need something a little different?

For manufacturers who wish to gain a competitive advantage through bright, stable and controllable illumination, CoolLED’s world-renowned LED technology is available in customised configurations.

Streamlined development using proven off-the-shelf technology
Professional support
Market-leading warranty
‘Try before you buy’ option
Trusted experts in LED illumination technology since 2006

LEARN MORE

Sustainability

Did you know that LED illumination systems help laboratories reduce their carbon footprint, protecting laboratory staff along the way?

Toxic mercury-based microscope illuminators are bad news for the environment, draw a lot of power and have a short lifetime.

LED illumination systems are cleaner, have a long lifetime and use less power. Our pE-300 Series is also ACT label certified and is a natural choice for labs who want to play their part in helping the environment.