Satoh, Y., Sato, H., Kunitomo, H., Fei, X., Hashimoto, K., & Iino, Y.
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan, Department of Intelligent Information Systems, Faculty of Science and Technology, Tohoku Bunka Gakuen University, Aoba-ku, Sendai 980-8579, Japan, Department of System Information Sciences, Graduate School of Information Sciences, Tohoku University, Aoba-ku, Sendai 980-8579, Japan, and CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.
The nematode Caenorhabditis elegans changes its chemotaxis to NaCl depending on previous experience. At the behavioural level, this chemotactic plasticity is generated by reversing the elementary behaviours for chemotaxis, klinotaxis, and klinokinesis. Here, we report that bidirectional klinotaxis is achieved by the proper use of at least two different neural subcircuits. We simulated a NaCl concentration change by activating an NaCl-sensitive chemosensory neuron in phase with head swing and successfully induced klinotaxis-like curving. The curving direction reversed depending on preconditioning, which was consistent with klinotaxis plasticity under a real concentration gradient. Cell-specific ablation and activation of downstream interneurons revealed that ASER-evoked curving toward lower concentration was mediated by AIY interneurons, whereas curving to the opposite direction was not. These results suggest that the experience-dependent bidirectionality of klinotaxis is generated by a switch between different neural subcircuits downstream of the chemosensory neuron.
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The Journal of Neuroscience
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