Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

Authors

Kieran A Boyle, Erika Polgar, Maria Gutierrez-Mecinas, Allen C Dickie, Andrew H Cooper, Andrew M Bell, Evelline Jumolea, Adrian Casas-Benito, Masahiko Watanabe, David I Hughes, Gregory A Weir, John S Riddell, Andrew J Todd

Topic

Neuroscience, Optogenetics

Extract

"The presence of optogenetically activated currents were observed in voltage clamp mode, from a holding potential of −70 mV, by illuminating the slice with brief (1–4 ms) pulses of blue light, generated by a 470-nm LED (CoolLED pE-100, Andover, UK) and delivered via the microscope objective."

Product Type

pE-100

Journal

eLife

Year of Publication

2023

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