Local PI(4,5)P2 synthesis by septin-associated PIPKIγ isoforms controls centralspindlin association with the midbody during cytokinesis

Authors

Giulia Russo, Nadja Hümpfer, Nina Jaensch, Steffen Restel, Christopher Schmied, Florian Heyd, Martin Lehmann, Helge Ewers, Volker Haucke, Michael Krauss

Topic

Cell Biology, Time-Lapse Microscopy

Extract

"For the experiment depicted in Fig. 1 and Supplementary Fig. 1b, semi-automated epi-fluorescent imaging was conducted with a Nikon Eclipse Ti microscope (illumination: CoolLED, pE4000, prime95B sCMOS camera) operated by NIS-Elements software, using a 20× air objective (0.75 NA)."

Product Type

pE-4000

Journal

Nature Communications

Year of Publication

2026

Read the full research paper here

Custom Microscopy Illumination

Need something a little different?

For manufacturers who wish to gain a competitive advantage through bright, stable and controllable illumination, CoolLED’s world-renowned LED technology is available in customised configurations.

Streamlined development using proven off-the-shelf technology
Professional support
Market-leading warranty
‘Try before you buy’ option
Trusted experts in LED illumination technology since 2006

LEARN MORE

Sustainability

Did you know that LED illumination systems help laboratories reduce their carbon footprint, protecting laboratory staff along the way?

Toxic mercury-based microscope illuminators are bad news for the environment, draw a lot of power and have a short lifetime.

LED illumination systems are cleaner, have a long lifetime and use less power. Our pE-300 Series is also ACT label certified and is a natural choice for labs who want to play their part in helping the environment.