Evaluation of Lipid Nanoparticles as Vehicles for Optogenetic Delivery in Primary Cortical Neurons

Authors

José David Celdrán, Lawrence Humphreys, Maria Jose Verdú, Desirée González, Cristina Soto-Sánchez, Gema Martínez-Navarrete, Lucía Enríquez, Iván Maldonado, Idoia Gallego, Mohamed Mashal, Noha Attia, Gustavo Puras, José Luis Pedraz, Eduardo Fernández

Topic

Optogenetics

Extract

"Cell stimulation was performed using a monochromatic light source (pE-300 ultra, CoolLED, Andover, UK) during electrophysiological recordings. To assess photoresponses in ChrimsonR positive cells, we applied two 5 ms light pulses at 590 nm (20 W, 1 s interval)."

Product Type

pE-300^ultra

Journal

Pharmaceutics.

Year of Publication

2025

Read the full research paper here

Custom Microscopy Illumination

Need something a little different?

For manufacturers who wish to gain a competitive advantage through bright, stable and controllable illumination, CoolLED’s world-renowned LED technology is available in customised configurations.

Streamlined development using proven off-the-shelf technology
Professional support
Market-leading warranty
‘Try before you buy’ option
Trusted experts in LED illumination technology since 2006

LEARN MORE

Sustainability

Did you know that LED illumination systems help laboratories reduce their carbon footprint, protecting laboratory staff along the way?

Toxic mercury-based microscope illuminators are bad news for the environment, draw a lot of power and have a short lifetime.

LED illumination systems are cleaner, have a long lifetime and use less power. Our pE-300 Series is also ACT label certified and is a natural choice for labs who want to play their part in helping the environment.