Emergent glutamate & dopamine dysfunction in VPS35(D620N) knock-in mice and rapid reversal by LRRK2 inhibition

Authors

A Kamesh, C A Kadgien, N Kuhlmann, S Coady, A Pietrantonio, Y Cousineau, A Khayachi, A Jurado Santos, E P Hurley, J C Barron, M P Parsons, A J Milnerwood

Topic

Neuroscience

Extract

"Imaging of iGluSnFR and dLight recordings were obtained using a 2X objective focused on dorsolateral STR. Slices were wide-field illuminated with blue light (473 nm, CoolLED pE-340fura), with the shutter, EM-CCD camera (Andor iXon Ultra 897), and stimulus isolator (WPI A365) triggered by Clampex & Digidata 1550B). "

Product Type

pE-340^fura

Journal

NPJ

Year of Publication

2025

Read the full research paper here

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