Stanicki, Dimitri Boutry, Sébastien Laurent, Sophie Wacheul, Ludivine Nicolas, Emilien Crombez, Deborah Vander Elst, Luce Lafontaine, Denis L. J. Muller, Robert N.
Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, B-7000 Mons, Belgium. Centre for Microscopy and Molecular Imaging, B-6041 Gosselies, Belgium cRNA Molecular Biology, Brussels, Belgium.
This study reports the synthesis of stabilized ultra-small iron oxide nanoparticles (USPIO) as bimodal probes for magnetic resonance and optical imaging. These nanosystems are based on small iron oxide cores surrounded by a thin polysiloxane shell exhibiting carboxylic acid functions. Thanks to these functions, hybrid particles were obtained by conjugating a fluorophore to the super paramagnetic contrastophore. Such modification allowed us to directly follow these USPIO in cellulo, which provided interesting information about their internalization pathway and cellular distribution upon mitosis. Finally, the efficiency of these systems as probes for bimodal imaging was emphasized by the observation of their in vivo behaviour in mice using magnetic resonance and optical imaging.
… “Cool-LED illuminator and a Roper HQ2 camera. (i) DIC (
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pE-100: A range of compact, simple-to-use, single wavelength illumination systems for screening fluorescence.
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Journal of Material Chemistry
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