Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor

Authors

Daniel Marks, Edwin Garcia, Sunil Kumar, Katie Tyson, Caroline Koch, Aleksandar P Ivanov, Joshua B Edel, Hasan B Mirza, William Flanagan, Christopher Dunsby, Paul MW French, Iain A McNeish

Topic

Medical Research

Extract

"The sample was excited via widefield illumination using an LED light engine at 365 nm (CoolLED, pE-4000) coupled via a 360/50 emission filter and 460/50 emission filter (Chroma, 49000 ET) to image intracellular rucaparib using a 20×0.95NA water immersion objective (Nikon, MRD77200)."

Product Type

pE-4000

Journal

Elsevier

Year of Publication

2025

Read the full research paper here

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