Pan, S., & Luo, C.
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China, Department of Neurology, Guangxi Minzu Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
Abstract Several studies have demonstrated that mild hypothermia exhibits a neuro-protective role and it can inhibit endothelial cell apoptosis following ischemia/reperfusion injury by decreasing casp-ase-3 expression. It is hypothesized that mild hypothermia exhibits neuro-protective effects on neurons exposed to ischemia/reperfusion condition produced by oxygen-glucose deprivation. Mild hypothermia significantly reduced the number of apoptotic neurons, decreased the expression of pro-apoptotic protein Bax and increased mitochondrial membrane potential, with the peak of anti-apoptotic effect appearing between 6 and 12 hours after the injury. These findings indicate that mild hypothermia inhibits neuronal apoptosis following ischemia/reperfusion injury by protecting the mitochondria and that the effective time window is 6–12 hours after ischemia/reperfusion injury.
… “were acquired with an inverted micro- scope equipped with a CoolLED fluorescent light source (Olympus, Tokyo, Japan)”…
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Neural Regeneration Research
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